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Most Known Citrus L. Species and Breast Cancer Relationship

Yıl 2024, Cilt: 6 Sayı: 1, 36 - 51, 30.04.2024
https://doi.org/10.59124/guhes.1407399

Öz

The genus Citrus L. belongs to the Rutaceae family of flowering plants and shrubs. Citrus genus has valuable edible fruits such as oranges, lemons, grapefruits, pomelos, and limes. Australia, Melanesia, Southeast Asia, East Asia, and South Asia are the native habitats of the genus Citrus. Indigenous societies in these regions have long utilized and tamed various Citrus species. Citrus fruits and their secondary metabolites have been reported to be useful agents in numerous studies to possess anti-inflammatory, antioxidant, and anticancer properties. This review gives an overview of Citrus species and background information on the potential anticancer properties of the compounds identified, along with the related in vitro and in vivo research. Studies from the past have revealed a variety of biological functions that Citrus compounds can regulate, such as angiogenesis, apoptosis, metastasis, cell cycle regulation, and cell proliferation. These promising data call for more investigation into the chemopreventative activity of Citrus and phytoconstituents.

Kaynakça

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  • Agouillal, F., Taher, Z. M., Moghrani, H., Nasrallah, N., & El Enshasy, H. (2017). A Review of Genetic Taxonomy, Biomolecules Chemistry and Bioactivities of Citrus hystrix DC. Biosciences Biotechnology Research Asia, 14(1), 285. https://doi.org/10.13005/bbra/2446
  • Al-Ataby, I. A., & Talib, W. H. (2022). Daily Consumption of Lemon and Ginger Herbal Infusion Caused Tumor Regression and Activation of the Immune System in a Mouse Model of Breast Cancer. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.829101
  • Alquézar, B., Rodrigo, M. J., & Zacarías, L. (2008). Carotenoid biosynthesis and their regulation in citrus fruits. Tree and Forestry Science and Biotechnology, 2(1), 23-37.
  • Alshatwi, A. A., Shafi, G., Hasan, T. N., Al-Hazzani, A. A., Alsaif, M. A., Alfawaz, M. A., Lei, K., & Munshi, A. (2011). Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pacific Journal of Cancer Prevention, 12(6), 1555-1559.
  • Amalina, N., & Wahyuni, S. (2021). Cytotoxic effects of the synthesized Citrus aurantium peels extract nanoparticles against MDA-MB-231 breast cancer cells. Journal of Physics: Conference Series,
  • Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Kaviyani, N., & Tavakol, S. (2020). Monoterpenes modulating autophagy: A review study. Basic & Clinical Pharmacology & Toxicology, 126(1), 9-20. https://doi.org/10.1111/bcpt.13282
  • Benson, J. R., Jatoi, I., Keisch, M., Esteva, F. J., Makris, A., & Jordan, V. C. (2009). Early breast cancer. The Lancet, 373(9673), 1463-1479. https://doi.org/10.1016/S0140-6736(09)60316-0
  • Bhuiyan, M. N. I., Begum, J., Sardar, P., & Rahman, M. (2009). Constituents of peel and leaf essential oils of Citrus medica L. Journal of Scientific Research, 1(2), 387-392. https://doi.org/10.3329/jsr.v1i2.1760
  • Cebadera-Miranda, L., Morales, P., & Cámara, M. (2020). Bioactive compounds in oranges from the Mediterranean climate area. In The Mediterranean Diet (pp. 293-309). Elsevier. https://doi.org/10.1016/B978-0-12-818649-7.00027-8
  • Chen, S., Wang, X., Cheng, Y., Gao, H., & Chen, X. (2023). A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids. Molecules, 28(13), 4982. https://doi.org/10.3390/molecules28134982
  • Chhikara, B. S., & Parang, K. (2023). Global Cancer Statistics 2022: the trends projection analysis. Chemical Biology Letters, 10(1), 451-451.
  • Cirmi, S., Ferlazzo, N., Lombardo, G. E., Maugeri, A., Calapai, G., Gangemi, S., & Navarra, M. (2016). Chemopreventive agents and inhibitors of cancer hallmarks: may citrus offer new perspectives? Nutrients, 8(11), 698. https://doi.org/10.3390/nu8110698
  • de Araújo, E. F., de Queiroz, L. P., & Machado, M. A. (2003). What is Citrus? Taxonomic implications from a study of cp-DNA evolution in the tribe Citreae (Rutaceae subfamily Aurantioideae). Organisms Diversity & Evolution, 3(1), 55-62. https://doi.org/10.1078/1439-6092-00058
  • Dugrand-Judek, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., & Bourgaud, F. (2015). The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PloS one, 10(11), e0142757. https://doi.org/10.1371/journal.pone.0142757
  • El-Kersh, D. M., Ezzat, S. M., Salama, M. M., Mahrous, E. A., Attia, Y. M., Ahmed, M. S., & Elmazar, M. M. (2021). Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific reports, 11(1), 1-14. https://doi.org/10.1038/s41598-021-86599-z
  • El Kamali, H. H., Burham, B. O., & El-Egami, A. A. (2015). Essential oil composition of internal fruit peel of Citrus paradisi from Sudan. American Research Thoughts, 1, 2079-2085. https://doi.org/10.6084/m9.figshare.1480470
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Yıl 2024, Cilt: 6 Sayı: 1, 36 - 51, 30.04.2024
https://doi.org/10.59124/guhes.1407399

Öz

Kaynakça

  • Agócs, A., Nagy, V., Szabó, Z., Márk, L., Ohmacht, R., & Deli, J. (2007). Comparative study on the carotenoid composition of the peel and the pulp of different citrus species. Innovative Food Science & Emerging Technologies, 8(3), 390-394. https://doi.org/10.1016/j.ifset.2007.03.012
  • Agouillal, F., Taher, Z. M., Moghrani, H., Nasrallah, N., & El Enshasy, H. (2017). A Review of Genetic Taxonomy, Biomolecules Chemistry and Bioactivities of Citrus hystrix DC. Biosciences Biotechnology Research Asia, 14(1), 285. https://doi.org/10.13005/bbra/2446
  • Al-Ataby, I. A., & Talib, W. H. (2022). Daily Consumption of Lemon and Ginger Herbal Infusion Caused Tumor Regression and Activation of the Immune System in a Mouse Model of Breast Cancer. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.829101
  • Alquézar, B., Rodrigo, M. J., & Zacarías, L. (2008). Carotenoid biosynthesis and their regulation in citrus fruits. Tree and Forestry Science and Biotechnology, 2(1), 23-37.
  • Alshatwi, A. A., Shafi, G., Hasan, T. N., Al-Hazzani, A. A., Alsaif, M. A., Alfawaz, M. A., Lei, K., & Munshi, A. (2011). Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pacific Journal of Cancer Prevention, 12(6), 1555-1559.
  • Amalina, N., & Wahyuni, S. (2021). Cytotoxic effects of the synthesized Citrus aurantium peels extract nanoparticles against MDA-MB-231 breast cancer cells. Journal of Physics: Conference Series,
  • Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Kaviyani, N., & Tavakol, S. (2020). Monoterpenes modulating autophagy: A review study. Basic & Clinical Pharmacology & Toxicology, 126(1), 9-20. https://doi.org/10.1111/bcpt.13282
  • Benson, J. R., Jatoi, I., Keisch, M., Esteva, F. J., Makris, A., & Jordan, V. C. (2009). Early breast cancer. The Lancet, 373(9673), 1463-1479. https://doi.org/10.1016/S0140-6736(09)60316-0
  • Bhuiyan, M. N. I., Begum, J., Sardar, P., & Rahman, M. (2009). Constituents of peel and leaf essential oils of Citrus medica L. Journal of Scientific Research, 1(2), 387-392. https://doi.org/10.3329/jsr.v1i2.1760
  • Cebadera-Miranda, L., Morales, P., & Cámara, M. (2020). Bioactive compounds in oranges from the Mediterranean climate area. In The Mediterranean Diet (pp. 293-309). Elsevier. https://doi.org/10.1016/B978-0-12-818649-7.00027-8
  • Chen, S., Wang, X., Cheng, Y., Gao, H., & Chen, X. (2023). A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids. Molecules, 28(13), 4982. https://doi.org/10.3390/molecules28134982
  • Chhikara, B. S., & Parang, K. (2023). Global Cancer Statistics 2022: the trends projection analysis. Chemical Biology Letters, 10(1), 451-451.
  • Cirmi, S., Ferlazzo, N., Lombardo, G. E., Maugeri, A., Calapai, G., Gangemi, S., & Navarra, M. (2016). Chemopreventive agents and inhibitors of cancer hallmarks: may citrus offer new perspectives? Nutrients, 8(11), 698. https://doi.org/10.3390/nu8110698
  • de Araújo, E. F., de Queiroz, L. P., & Machado, M. A. (2003). What is Citrus? Taxonomic implications from a study of cp-DNA evolution in the tribe Citreae (Rutaceae subfamily Aurantioideae). Organisms Diversity & Evolution, 3(1), 55-62. https://doi.org/10.1078/1439-6092-00058
  • Dugrand-Judek, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., & Bourgaud, F. (2015). The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PloS one, 10(11), e0142757. https://doi.org/10.1371/journal.pone.0142757
  • El-Kersh, D. M., Ezzat, S. M., Salama, M. M., Mahrous, E. A., Attia, Y. M., Ahmed, M. S., & Elmazar, M. M. (2021). Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific reports, 11(1), 1-14. https://doi.org/10.1038/s41598-021-86599-z
  • El Kamali, H. H., Burham, B. O., & El-Egami, A. A. (2015). Essential oil composition of internal fruit peel of Citrus paradisi from Sudan. American Research Thoughts, 1, 2079-2085. https://doi.org/10.6084/m9.figshare.1480470
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  • Klimek-Szczykutowicz, M., Szopa, A., & Ekiert, H. (2020). Citrus limon (Lemon) phenomenon—a review of the chemistry, pharmacological properties, applications in the modern pharmaceutical, food, and cosmetics industries, and biotechnological studies. Plants, 9(1), 119. https://doi.org/10.3390/plants9010119
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  • Kuttan, G., Pratheeshkumar, P., Manu, K. A., & Kuttan, R. (2011). Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical Biology, 49(10), 995-1007. https://doi.org/10.3109/13880209.2011.559476
  • Lemes, R. S., Alves, C. C., Estevam, E. B., Santiago, M. B., Martins, C. H., SANTOS, T. C. D., Crotti, A. E., & Miranda, M. L. (2018). Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria. Anais da Academia Brasileira de Ciências, 90, 1285-1292. https://doi.org/10.1590/0001-3765201820170847
  • Lin, L.-Y., Chuang, C.-H., Chen, H.-C., & Yang, K.-M. (2019). Lime (Citrus aurantifolia (Christm.) Swingle) essential oils: Volatile compounds, antioxidant capacity, and hypolipidemic effect. Foods, 8(9), 398. https://doi.org/10.3390/foods8090398
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  • Maksoud, S., Abdel-Massih, R. M., Rajha, H. N., Louka, N., Chemat, F., Barba, F. J., & Debs, E. (2021). Citrus aurantium L. active constituents, biological effects and extraction methods. an updated review. Molecules, 26(19), 5832. https://doi.org/10.3390/molecules26195832
  • Mayer, A. M., & Gustafson, K. R. (2004). Marine pharmacology in 2001–2: antitumour and cytotoxic compounds. European Journal of Cancer, 40(18), 2676-2704. https://doi.org/10.1016/j.ejca.2004.09.005
  • Miller, K. D., Nogueira, L., Devasia, T., Mariotto, A. B., Yabroff, K. R., Jemal, A., Kramer, J., & Siegel, R. L. (2022). Cancer treatment and survivorship statistics, 2022. CA: a Cancer Journal for Clinicians, 72(5), 409-436. https://doi.org/10.3322/caac.21149
  • Musa, M. A., Cooperwood, J. S., & Khan, M. O. F. (2008). A review of coumarin derivatives in pharmacotherapy of breast cancer. Current Medicinal Chemistry, 15(26), 2664-2679. https://doi.org/10.2174/092986708786242877
  • Narayanankutty, A., Visakh, N. U., Sasidharan, A., Pathrose, B., Olatunji, O. J., Al-Ansari, A., Alfarhan, A., & Ramesh, V. (2022). Chemical Composition, Antioxidant, Anti-Bacterial, and Anti-Cancer Activities of Essential Oils Extracted from Citrus limetta Risso Peel Waste Remains after Commercial Use. Molecules, 27(23), 8329. https://doi.org/10.3390/molecules27238329
  • Okla, M. K., Alamri, S. A., Salem, M. Z., Ali, H. M., Behiry, S. I., Nasser, R. A., Alaraidh, I. A., Al-Ghtani, S. M., & Soufan, W. (2019). Yield, phytochemical constituents, and antibacterial activity of essential oils from the leaves/twigs, branches, branch wood, and branch bark of Sour Orange (Citrus aurantium L.). Processes, 7(6), 363. https://doi.org/10.3390/pr7060363
  • Ollitrault, P., Curk, F., & Krueger, R. (2020). Citrus taxonomy. In The genus citrus (pp. 57-81). Elsevier. https://doi.org/10.1016/B978-0-12-812163-4.00004-8
  • Olson, J. A. (1999). Carotenoids and human health. Archivos Latinoamericanos de Nutrición, 49(3 Suppl 1), 7S-11S.
  • Oyebadejo, S. A., Joseph, O. S., Adesite, S. O., & Abia, E. R. (2019). Effect of Citrus Limon Juice And Tamoxifen on the Oxidative Stress Activities of Mcf-7 Cell Induced Breast Cancer In Sprawgue Dawley Rats. World Journal of Pharmacy and Pharmaceutical Sciences, 8(7), 76-92. https://doi.org/10.20959/wjpps20197-14087
  • Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: an overview. Journal of Nutritional Science, 5, e47. https://doi.org/10.1017/jns.2016.41
  • Paoli, M., de Rocca Serra, D., Tomi, F., Luro, F., & Bighelli, A. (2016). Chemical composition of the leaf essential oil of grapefruits (Citrus paradisi Macf.) in relation with the genetic origin. Journal of Essential Oil Research, 28(4), 265-271. https://doi.org/10.1080/10412905.2016.1140090
  • Park, M. Y., Kim, Y., Ha, S. E., Kim, H. H., Bhosale, P. B., Abusaliya, A., Jeong, S. H., & Kim, G. S. (2022). Function and application of flavonoids in the breast cancer. International Journal of Molecular Sciences, 23(14), 7732. https://doi.org/10.3390/ijms23147732
  • Paw, M., Begum, T., Gogoi, R., Pandey, S. K., & Lal, M. (2020). Chemical composition of Citrus limon L. Burmf peel essential oil from North East India. Journal of Essential Oil Bearing Plants, 23(2), 337-344. https://doi.org/10.1080/0972060X.2020.1757514
  • Petretto, G. L., Vacca, G., Addis, R., Pintore, G., Nieddu, M., Piras, F., Sogos, V., Fancello, F., Zara, S., & Rosa, A. (2023). Waste Citrus limon Leaves as Source of Essential Oil Rich in Limonene and Citral: Chemical Characterization, Antimicrobial and Antioxidant Properties, and Effects on Cancer Cell Viability. Antioxidants, 12(6), 1238. https://doi.org/10.3390/antiox12061238
  • Prince, M., Li, Y., Childers, A., Itoh, K., Yamamoto, M., & Kleiner, H. E. (2009). Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. Toxicology Letters, 185(3), 180-186. https://doi.org/10.1016/j.toxlet.2008.12.014
  • Qiu, M., Wei, W., Zhang, J., Wang, H., Bai, Y., & Guo, D.-a. (2023). A Scientometric Study to a Critical Review on Promising Anticancer and Neuroprotective Compounds: Citrus Flavonoids. Antioxidants, 12(3), 669. https://doi.org/10.3390/antiox12030669
  • Rao, A. V., & Rao, L. G. (2007). Carotenoids and human health. Pharmacological Research, 55(3), 207-216. https://doi.org/10.1016/j.phrs.2007.01.012
  • Rouseff, R. L., Ruiz Perez-Cacho, P., & Jabalpurwala, F. (2009). Historical review of citrus flavor research during the past 100 years. Journal of Agricultural and Food Chemistry, 57(18), 8115-8124. https://doi.org/10.1021/jf900112y
  • Rowles III, J. L., & Erdman Jr, J. W. (2020). Carotenoids and their role in cancer prevention. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(11), 158613. https://doi.org/10.1016/j.bbalip.2020.158613
  • Saini, R. K., Keum, Y.-S., Daglia, M., & Rengasamy, K. R. (2020). Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence. Pharmacological Research, 157, 104830. https://doi.org/10.1016/j.phrs.2020.104830
  • Saleem, M., Afza, N., Aijaz Anwar, M., & Ali, M. S. (2005). Aromatic constituents from fruit peels of Citrus reticulata. Natural Product Research, 19(6), 633-638. https://doi.org/10.1080/14786410512331330701
  • Sandoval-Montemayor, N. E., García, A., Elizondo-Treviño, E., Garza-González, E., Alvarez, L., & del Rayo Camacho-Corona, M. (2012). Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. Molecules, 17(9), 11173-11184. https://doi.org/10.3390/molecules170911173
  • Saranya, A., Sivakumari, K., Ashok, K., & Rajesh, S. (2017). Phyto-chemical profiling and anti-cancer study of lyophilized pure fruit juice of Citrus limon (L) Osbeck against human breast cancer (MCF-7) cell line. J. Adv. Mol. Biol, 1(2), 90-103. https://doi.org/10.22606/jamb.2017.12002
  • Segun, P. A., Ismail, F. M., Ogbole, O. O., Nahar, L., Evans, A. R., Ajaiyeoba, E. O., & Sarker, S. D. (2018). Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells. Journal of Ethnopharmacology, 227, 131-138. https://doi.org/10.1016/j.jep.2018.08.039
  • Senkus, E., Kyriakides, S., Ohno, S., Penault-Llorca, F., Poortmans P., Rutgers, E., Zackrisson, S., & Cardoso, F. (2015). Primary breast cancer: ESMO ClinicalPractice Guidelines for diagnosis, treatment nd follow-up. Annals of Oncology, 26, v8-v30. htts://doi.org/10.1093/annonc/mdv298
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  • Visakh, N. U., Pathrose, B., Narayanankutty, A., Alfarhan, A., & Ramesh, V. (2022). Utilization of pomelo (Citrus maxima) peel waste into bioactive essential oils: Chemical composition and insecticidal properties. Insects, 13(5), 480. https://doi.org/10.3390/insects13050480
  • Waks, A. G., & Winer, E. P. (2019). Breast cancer treatment: a review. Jama, 321(3), 288-300. https://doi.org/10.1001/jama.2018.19323
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  • Wangensteen, H., Molden, E., Christensen, H., & Malterud, K. (2003). Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. European Journal of Clinical Pharmacology, 58(10), 663-668. https://doi.org/10.1007/s00228-002-0537-3
  • Wu, L., Wang, X., Xu, W., Farzaneh, F., & Xu, R. (2009). The structure and pharmacological functions of coumarins and their derivatives. Current Medicinal Chemistry, 16(32), 4236-4260. https://doi.org/10.2174/092986709789578187
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  • Zhang, Y., Sun, Y., Xi, W., Shen, Y., Qiao, L., Zhong, L., Ye, X., & Zhou, Z. (2014). Phenolic compositions and antioxidant capacities of Chinese wild mandarin (Citrus reticulata Blanco) fruits. Food Chemistry, 145, 674-680. https://doi.org/10.1016/j.foodchem.2013.08.012
Toplam 71 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Makaleler
Yazarlar

Ömer Faruk Yakıncı 0000-0002-9628-9376

İpek Süntar 0000-0003-4201-1325

Yayımlanma Tarihi 30 Nisan 2024
Gönderilme Tarihi 20 Aralık 2023
Kabul Tarihi 12 Ocak 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 6 Sayı: 1

Kaynak Göster

APA Yakıncı, Ö. F., & Süntar, İ. (2024). Most Known Citrus L. Species and Breast Cancer Relationship. Journal of Gazi University Health Sciences Institute, 6(1), 36-51. https://doi.org/10.59124/guhes.1407399