Öz
Kaynakça
- Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766.
- Imtiaz F., Shafique K., Mirza S.S., Ayoob Z., Vart P., Rao S. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5:2.
- Asahina A., Kubo N., Umezawa Y., Honda H., Yanaba K., Nakagawa H. Neutrophil–lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: response to therapy with biologics. J Dermatol. 2017;44:1112–1121.
- Ghattas A., Griffiths H.R., Devitt A., Lip G.Y., Shantsila E. Monocytes in coronary artery disease and atherosclerosis: where are we now? J Am Coll Cardiol. 2013;62:1541–1551.
- Murphy AJ, Westerterp M, Yvan-Charvet L,Tall AR. Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells. Biochim Biophys Acta 2012;1821, 513–521.
- Demirbaş A, Elmas ÖF, Atasoy M, Türsen Ü, Lotti T. Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study. Arch Dermatol Res. 2021;313(6):491-498.
- Sirin MC, Korkmaz S, Erturan I, et al. Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis. An Bras Dermatol. 2020;95(5):575-582.
- Aktaş Karabay E, Demir D, Aksu Çerman A. Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis. An Bras Dermatol. 2020;95(1):40-45.
- Kolkhir P, Andre F, Church MK, Maurer M, Metz Potential blood biomarkers in chronic spontaneous urticaria. Clin Exp Allergy. 2017;47(1):19-36.
- Vena GA, Cassano N. The link between chronic spontaneous urticaria and metabolic syndrome. Eur Ann Allergy Clin Immunol. 2017;49(5):208-212.
- Ye YM, Jin HJ, Hwang EK, et al. Co-existence of chronic urticaria and metabolic syndrome: clinical implications. Acta Derm Venereol. 2013;93(2):156-160.
- Madsen CM, Varbo A, Nordestgaard BG. Low HDL cholesterol and high risk of autoimmune disease: two population-based cohort studies including 117341 individuals. Clin Chem. 2019;65(5):644-652.
- Shalom G, Magen E, Babaev M, et al. Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients. J Eur Acad Dermatol Venereol. 2018;32(2):276-281.
- Feng F, Tian Y, Liu S, et al. Combination of PLR, MLR MWR, and tumor size could significantly increase the prognostic value for gastrointestinal stromal tumors. Medicine (Baltimore). 2016;95:e3248.
- Ertaş R, Özyurt K, Karakükçü Ç, et al. Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria. Turk J Med Sci. 2018;48(6):1255-1262.
- Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9(1):30.
Monocyte-to-HDL Cholesterol Ratio As A New Parameter of Systemic Inflammation and Disease Severity in Treatment-Resistant Chronic Spontaneous Urticaria
Öz
Background and Purpose: Chronic spontaneous urticaria (CSU) is characterized by inflammation and increased oxidative stress in its pathogenesis. The study aims to evaluate new inflammatory markers indicating systemic inflammation in resistant CSU and to determine their relationship with disease severity.
Methods: The files of CSU patients and matched healthy volunteers were reviewed and compared in terms of demographics, medical history, clinical features, laboratory parameters, and new inflammatory markers [NLR:neutrophil-lymphocyte ratio, MLR: monocyte-lymphocyte ratio, MHR:monocyte-to-high-density lipoprotein cholesterol (HDL-C)].
Results: Sixty-one CSU patients and 50 healthy controls were evaluated (female: male ratio=1.9:1, mean age=43.97 ± 14.88 years). The median erythrocyte sedimentation rate, C-reactive protein (CRP), white blood cell, monocyte count, and MHR were higher in the CSU group; in contrast, the mean HDL-C level was lower. The median NLR and MLR were also higher in the CSU group but were not statistically significant. Urticaria activity score 7 (UAS7) was positively correlated with MHR and negatively correlated with HDL-C. MHR was positively correlated with MLR, CRP, and UAS7.
Conclusions: MHR might serve as an indicator of inflammation intensity and predisposition to MS in CSU patients. It might also be used as an objective tool for evaluating disease severity and treatment response in CSU.
Anahtar Kelimeler
Chronic spontan urticaria, c-reaktive protein inflammation metabolic syndrome monocyte-to-HDL ratio
Kaynakça
- Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766.
- Imtiaz F., Shafique K., Mirza S.S., Ayoob Z., Vart P., Rao S. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5:2.
- Asahina A., Kubo N., Umezawa Y., Honda H., Yanaba K., Nakagawa H. Neutrophil–lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: response to therapy with biologics. J Dermatol. 2017;44:1112–1121.
- Ghattas A., Griffiths H.R., Devitt A., Lip G.Y., Shantsila E. Monocytes in coronary artery disease and atherosclerosis: where are we now? J Am Coll Cardiol. 2013;62:1541–1551.
- Murphy AJ, Westerterp M, Yvan-Charvet L,Tall AR. Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells. Biochim Biophys Acta 2012;1821, 513–521.
- Demirbaş A, Elmas ÖF, Atasoy M, Türsen Ü, Lotti T. Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study. Arch Dermatol Res. 2021;313(6):491-498.
- Sirin MC, Korkmaz S, Erturan I, et al. Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis. An Bras Dermatol. 2020;95(5):575-582.
- Aktaş Karabay E, Demir D, Aksu Çerman A. Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis. An Bras Dermatol. 2020;95(1):40-45.
- Kolkhir P, Andre F, Church MK, Maurer M, Metz Potential blood biomarkers in chronic spontaneous urticaria. Clin Exp Allergy. 2017;47(1):19-36.
- Vena GA, Cassano N. The link between chronic spontaneous urticaria and metabolic syndrome. Eur Ann Allergy Clin Immunol. 2017;49(5):208-212.
- Ye YM, Jin HJ, Hwang EK, et al. Co-existence of chronic urticaria and metabolic syndrome: clinical implications. Acta Derm Venereol. 2013;93(2):156-160.
- Madsen CM, Varbo A, Nordestgaard BG. Low HDL cholesterol and high risk of autoimmune disease: two population-based cohort studies including 117341 individuals. Clin Chem. 2019;65(5):644-652.
- Shalom G, Magen E, Babaev M, et al. Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients. J Eur Acad Dermatol Venereol. 2018;32(2):276-281.
- Feng F, Tian Y, Liu S, et al. Combination of PLR, MLR MWR, and tumor size could significantly increase the prognostic value for gastrointestinal stromal tumors. Medicine (Baltimore). 2016;95:e3248.
- Ertaş R, Özyurt K, Karakükçü Ç, et al. Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria. Turk J Med Sci. 2018;48(6):1255-1262.
- Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9(1):30.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ocak 2023 |
| Gönderilme Tarihi | 27 Kasım 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 7 Sayı: 1 |
